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Proposed regulation of Msx2 via BMP receptor-mediated PR signaling.

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posted on 2013-02-20, 07:28 authored by Jodie M. Fleming, Erika Ginsburg, Anita S. Goldhar, Joshua Plant, Barbara K. Vonderhaar

Progesterone receptor signaling upregulates Msx2 transcription via inhibition of the phosphatase Akp2 and upregulation of Alk2 activity, leading to phosphorylation and nuclear translocation of the Smad transcription factor proteins.