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Postnatal CDPPB treatment decreased [11C]PBR accumulation in saline-exposed offspring, but not in offspring prenatally exposed to LPS.

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posted on 04.11.2015, 04:39 by Dany Arsenault, Katherine Coulombe, Aijun Zhu, Chunyu Gong, Kun-Eek Kil, Ji-Kyung Choi, Pekka Poutiainen, Anna-Liisa Brownell

Postnatal CDPPB treatment decreased the accumulation of [11C]PBR in the olfactory bulb, cerebellum, hippocampus, striatum, hypothalamus and the whole brain of the offspring prenatally exposed to saline solution (A). However, [11C]PBR accumulation did not change in any quantified brain region of the LPS-exposed offspring (B). Axial PET images of [11C]PBR accumulation at the midbrain level illustrate the decreased accumulation after CDPPB treatment in the prenatally saline-exposed offspring while there is no significant change in the brain of CDPPB treated mice prenatally exposed to LPS (C). Values are expressed as mean ± SEM. Abbreviations: CDPPB, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide; [11C] PBR28, peripheral benzodiazepine receptor 28; Ctx, cortex; Crbl, cerebellum; Hip, hippocampus; Hth, hypothalamus; OB, olfactory bulb; PnD, postnatal day; Str, striatum; W, whole brain. *p < 0.05, **p < 0.01 >>