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Polyfunctional profiles of CSP-specific CD4 T cells one month post last immunization.

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posted on 27.04.2011, 00:12 by Daniel Ansong, Kwaku P. Asante, Johan Vekemans, Sandra K. Owusu, Ruth Owusu, Naana A. W. Brobby, David Dosoo, Alex Osei-Akoto, Kingsley Osei-Kwakye, Emmanuel Asafo-Adjei, Kwadwo O. Boahen, Justice Sylverken, George Adjei, David Sambian, Stephen Apanga, Kingsley Kayan, Michel H. Janssens, Marc J. J. Lievens, Aurelie C. Olivier, Erik Jongert, Patrice Dubois, Barbara M. Savarese, Joe Cohen, Sampson Antwi, Brian M. Greenwood, Jennifer A. Evans, Tsiri Agbenyega, Philippe J. Moris, Seth Owusu-Agyei

Polyfunctional profiles of CSP-specific CD4 T cells expressing any combination of immune markers among IL-2, TNF-α, IFN-γ, and CD40L in infants and children aged 5–17 months from Kintampo, vaccinated with RTS,S/AS01E or rabies vaccine according to a 0,1,2-month immunization schedule. Data are represented as background subtracted geometric mean number of CSP-specific CD4 T cells expressing any combination of IL-2, TNF-α, IFN-γ, and/or CD40L per 106 CD4 T cells, with 95% CI (A). The pie chart represents the proportion of CSP-specific CD4 T cells expressing 1, 2, 3 or 4 immune markers amongst IL-2, TNF-α, IFN-γ, and CD40L from RTS,S/AS01E recipients (B).

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