Plots of the sensitivity and specificity of each program (a–e) and a consensus of any two or all three of the top three methods at identifying the known epitopes for each FMDV structure selected represented as black dots on the pyramid plot.

Pyramid probability represents scales of sensitivity and specificity, with the probability excess increasing with height and a perfect prediction (where both the sensitivity and specificity score a value of 1) coming at the tip of the pyramid. The bottom line of the plot represents the point at which results would be expected to be generated by chance.