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Download filePlots of the sensitivity and specificity of each program (a–e) and a consensus of any two or all three of the top three methods at identifying the known epitopes for each FMDV structure selected represented as black dots on the pyramid plot.
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posted on 2013-05-07, 02:18 authored by Daryl W. Borley, Mana Mahapatra, David J. Paton, Robert M. Esnouf, David I. Stuart, Elizabeth E. FryPyramid probability represents scales of sensitivity and specificity, with the probability excess increasing with height and a perfect prediction (where both the sensitivity and specificity score a value of 1) coming at the tip of the pyramid. The bottom line of the plot represents the point at which results would be expected to be generated by chance.
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pentamer-pentamer interfaceFMDVcross-reactive vaccinesvirus capsidsnovel residuesserotypeIn-Silico Structure-Based Epitope PredictionFoot-and-Mouth Disease Virusnovel epitopescomputer programssemi-automated procedurevirus-specific softwareVP 2VP 3VP 1foot-and-mouth disease virusantigenic residuesstructure-based B cell epitope prediction programsglobular proteinsepitope prediction methodconsensus resultsprediction algorithmsvirus antigenicityprinciple concept3 D structure
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