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Plot of ln(rbnd/rm) vs. runtime integral revealing a loss integral.

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posted on 2015-03-24, 03:58 authored by Kristian Schilling, Frank Krause

A discrete amount of centrifugal force has not contributed to displacement of the sedimentation boundary, but was needed to overcome surface tension at the meniscus.

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Analysis of Antibody Aggregate Content at Extremely High Concentrations Using Sedimentation Velocity with a Novel Interference Optics
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interference profilesprotein concentrationsExtremely High Concentrationssize distributionchemical propertiespost-translational modificationssample-matrix interactionsSedimentation Velocitysize variantsantibodysugar-based excipientsconcentration gradientsnon-ideal sedimentation behaviorprotein-based biopharmaceuticalsSV analysissize-exclusion chromatographyproduct formulationaggregation analysis methodsNovel Interference Opticssedimentation velocityAdvanced Interference Detection ArrayAIDA ultracentrifuge

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