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Participation of nPKC and PKD1 in the feedback monomerization of the EGFR.

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posted on 14.10.2015, 04:12 by Malgorzata Kluba, Yves Engelborghs, Johan Hofkens, Hideaki Mizuno

(A) Time traces of diffusion coefficient of EGFRwt in the presence of the PKC activator PMA (upper) or under nominally Ca2+-free conditions (lower panel). In red, the time trace of cytosolic Ca2+ concentration monitored with Fura Red is shown. (B) Time traces of diffusion coefficient of eGFP-EGFRwt in the cell coexpressing constitutively active mutant, mCherry-PKD1S738/742E (upper), in the cell pre-treated with 10 μM CID755673, PKD1 inhibitor (middle), or in the cell coexpressing kinase deficient mutant, mCherry-PKD1K612W (lower panel).