Fig_2.tif (420.3 kB)

Partial CLUSTAL 2.1 multiple sequence alignment of publicly available Brugia malayi (Bm1_48165), Homo sapiens (HsSAH), Saccharomyces cerevisiae (ScSAH), and our cloned Brugia malayi (BmSAH) S-adenosyl homocysteinases, showing the “insert” missing from the publicly available nematode protein sequence.

Download (0 kB)
posted on 28.01.2016 by Elizabeth Bilsland, Daniel M. Bean, Eileen Devaney, Stephen G. Oliver

The absence of the 27 amino acids in the publicly available Brugia sequence (Bm1_48165) could indicate a splice variant of the enzyme or simply a problem with the genome assembly.