PPD-specific proliferation is not impaired by L. sigmodontis co-infection.
A, Spleen cell proliferation in response to M. tuberculosis PPD and B, SEB. Cotton rats were infected with L. sigmodontis (L.s.) and/or M. tuberculosis (MTB), or were uninfected. Shown is the proliferation index (OD of stimulated cells/baseline). Statistical significance between groups were analyzed by the Kruskal-Wallis test, followed by Dunn's post-hoc multiple comparisons. Single stars show significant differences compared to the uninfected animals. Shown are representative results from one of two experiments. **p<0.01, ***p<0.001.