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PPD-specific proliferation is not impaired by L. sigmodontis co-infection.

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posted on 2013-02-19, 18:12 authored by Marc P. Hübner, Kristin E. Killoran, Michael Rajnik, Samuel Wilson, Kevin C. Yim, Marina N. Torrero, Christopher P. Morris, Boris Nikonenko, Jorge C. G. Blanco, Val G. Hemming, Edward Mitre

A, Spleen cell proliferation in response to M. tuberculosis PPD and B, SEB. Cotton rats were infected with L. sigmodontis (L.s.) and/or M. tuberculosis (MTB), or were uninfected. Shown is the proliferation index (OD of stimulated cells/baseline). Statistical significance between groups were analyzed by the Kruskal-Wallis test, followed by Dunn's post-hoc multiple comparisons. Single stars show significant differences compared to the uninfected animals. Shown are representative results from one of two experiments. **p<0.01, ***p<0.001.


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