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PPARα agonist partially restores liver damage but does not rescue CCR5-/- infected mice from mortality.

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posted on 13.08.2014 by Giuliano Bonfá, Luciana Benevides, Maria do Carmo Souza, Denise Morais Fonseca, Tiago Wilson Patriarca Mineo, Marcos Antônio Rossi, Neide Maria Silva, João Santana Silva, Cristina Ribeiro de Barros Cardoso

WT and CCR5-/- mice were infected with 5 cysts of T. gondii and treated with Gemfibrozil, 100 mg/Kg/day, during 7 days. At day 8 pi, livers were harvested, formalin-fixed, paraffin-embedded, stained with Hematoxylin and Eosin (H&E) and analyzed by light microscopy (A). Blood was collected and processed to serum analysis of triglycerides (B). Survival was accompanied until day 40 pi and treatment. The results were obtained with three to five animals per group and are representative of two independent experiments. GEM: Gemfibrozil; VEH: vehicle. * p<0.05 compared to WT mice. Scale bar: 100 µm.