PI3K inhibition decreased cystitis-induced increment of bladder weight measured in vitro and in vivo.
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The bladder mass was calculated by analyzing MRI data and using a formula described in the methodology (A). Postmortem measurement of the bladder weight showed an increase in cystitis animals when compared to control (B); this increment was reduced by LY294002 (LY) treatment (B). n = 4–5. *, p<0.05 vs vehicle control. #, p<0.05 vs CYP cystitis.