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Overview of the SNP2HLA imputation procedure.

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posted on 06.06.2013, 01:05 by Xiaoming Jia, Buhm Han, Suna Onengut-Gumuscu, Wei-Min Chen, Patrick J. Concannon, Stephen S. Rich, Soumya Raychaudhuri, Paul I.W. de Bakker

The reference panel (top) contains SNPs in the MHC, classical HLA alleles at the class I and class II loci, and amino acid sequences corresponding to the 4-digit HLA types at each locus. For a data set with genotyped SNPs across the MHC (bottom), we use the reference panel to impute classical alleles and their corresponding amino acid polymorphisms.