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Overview of experimental approach.

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posted on 2013-01-03, 01:01 authored by Anne L. Wheeler, Cátia M. Teixeira, Afra H. Wang, Xuejian Xiong, Natasa Kovacevic, Jason P. Lerch, Anthony R. McIntosh, John Parkinson, Paul W. Frankland

Mice were fear conditioned, and fear memory was tested after either a short- or long retention delay. In order to identify neurons activated by memory recall, following testing brain sections were stained for the activity-dependent gene c-fos. Fos expression was subsequently quantified in 84 brain regions, and a complete set of inter-regional correlations computed in order to identify collections of brain regions where Fos expression co-varies across mice. The most robust correlations were then used to generate functional networks for long-term fear memory, and network properties and hubs were characterized using graph theoretical approaches.


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