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Orthotopic xenograft “AVATAR” models recapitulate the subtypes of their parental GBMs.

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posted on 01.08.2014, 03:00 by Young Taek Oh, Hee Jin Cho, Jinkuk Kim, Ji-Hyun Lee, Kyoohyoung Rho, Yun-Jee Seo, Yeon-Sook Choi, Hye Jin Jung, Hyeon Suk Song, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Yeup Yoon, Sunghoon Kim, Do-Hyun Nam, Kyeung Min Joo

(A) Predicted molecular subtypes of 25 GBM patients from the SMC GBM dataset and corresponding orthotopic xenograft “AVATAR” models were summarized. *, matched case. PN = Proneural, NL = Neural, CL = Classical, MES = Mesenchymal, ND = not-determined. (B) Subtype classification of 25 GBM patients by the NTP methods was compared with subtypes of corresponding orthotopic xenograft “AVATAR” models.