Olig2/Sox2/radixin co-expression in the rostral migratory stream.
(A, B) Increased Olig2 immunoreactivity was observed after EGF infusion. (C, D) Olig2−/Sox2high cells (red arrows) were found in both control and EGF-treated rostral migratory stream (RMS) (A, C, E) In the control RMS, Olig2 positive cells are few and either Sox2 negative (green arrows) or express Sox2high (B, D, F) The expanded radixin+/Olig2+ population in the EGF-treated RMS express Sox2high (yellow arrows). (E, F) Olig2+ cells negative for Sox2 were observed under both conditions (green arrows). Scale bar in A = 50 µm.