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Olfactory parameters and their modulations by the TRPA1 rs11988795 G>A genotype (wild type subjects, GG, versus carriers of the minor A allele).

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posted on 21.04.2014, 10:01 by Michael Schütz, Bruno G. Oertel, Dirk Heimann, Alexandra Doehring, Carmen Walter, Violeta Dimova, Gerd Geisslinger, Jörn Lötsch

From left to right: (i) In cross-tabulation of normosmic (N) versus hyposmic (H) subjects, hyposmic subjects were underrepresented among the carriers of the A allele (likelihood ratio test: p = 0.049). (ii) This genotypic association was more produced in the performance in the odor discrimination subtest of the Sniffn’ Sticks test battery [18], where carriers of the A allele performed significantly better (t-test: p = 0.029). (iii and iv): The other olfactory tests, however, were unaffected by the TRPA1 genotype (odor threshold and odor identification). (v) The genotype effects were most pronounced in the perceived intensity of olfactory H2S stimuli administered with an olfactometer (p = 0.006). The widths of the bars or boxes are proportional to the respective numbers of subjects per group. *: p<0.05, **: p<0.01. The minimum, quartiles, median (solid horizontal line within the box), and maximum are used to construct the box plots.

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