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Nutlin pharmacokinetics: Data from Zhang et al. [58] (total Nutlin concentration in mouse retina after oral delivery, black dots), and fittings by the model (8).

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posted on 11.12.2014, 02:54 authored by Krzysztof Puszynski, Alberto Gandolfi, Alberto d'Onofrio

Doses: panel A, 100 mg/Kg; panel B, 200 mg/Kg.

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The Pharmacodynamics of the p53-Mdm2 Targeting Drug Nutlin: The Role of Gene-Switching Noise
PLOS Computational BiologyPLOS Computational Biology

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doseMdm 2ptennutlinregulationthresholdmodelp 53 levelloop

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