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Notch receptors 1–3 do not detectably alter the DNA binding-site preferences of CSL-His6.

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posted on 24.11.2010, 01:52 by Cristina Del Bianco, Anastasia Vedenko, Sung Hee Choi, Michael F. Berger, Leila Shokri, Martha L. Bulyk, Stephen C. Blacklow

DNA binding specificity motifs and 8-mer PBM enrichment scores were calculated for complexes comprised of A) CSL-His6 and GST-Notch1, B) CSL-His6 and GST-Notch2 and C) CSL-His6 and GST-Notch3. Motifs were derived using the Seed-and-Wobble algorithm as previously described [20], [31].