Figure_5.tif (1.06 MB)

Notch receptors 1–3 do not detectably alter the DNA binding-site preferences of CSL-His6.

Download (0 kB)
posted on 24.11.2010 by Cristina Del Bianco, Anastasia Vedenko, Sung Hee Choi, Michael F. Berger, Leila Shokri, Martha L. Bulyk, Stephen C. Blacklow

DNA binding specificity motifs and 8-mer PBM enrichment scores were calculated for complexes comprised of A) CSL-His6 and GST-Notch1, B) CSL-His6 and GST-Notch2 and C) CSL-His6 and GST-Notch3. Motifs were derived using the Seed-and-Wobble algorithm as previously described [20], [31].