Notch receptors 1–3 do not detectably alter the DNA binding-site preferences of CSL-His<sub>6</sub>.
figure
posted on 2010-11-24, 01:52 authored by Cristina Del Bianco, Anastasia Vedenko, Sung Hee Choi, Michael F. Berger, Leila Shokri, Martha L. Bulyk, Stephen C. Blacklow<p>DNA binding specificity motifs and 8-mer PBM enrichment scores were calculated for complexes comprised of A) CSL-His<sub>6</sub> and GST-Notch1, B) CSL-His<sub>6</sub> and GST-Notch2 and C) CSL-His<sub>6</sub> and GST-Notch3. Motifs were derived using the Seed-and-Wobble algorithm as previously described <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015034#pone.0015034-Berger2" target="_blank">[20]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015034#pone.0015034-Berger4" target="_blank">[31]</a>.</p>
