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Normalized force-pCa relationships in Tnnt2+//TGWT and Tnnt2+//TGK210Δ skinned papillary muscle fibers.

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posted on 21.02.2013, 10:03 by Ferhaan Ahmad, Sanjay K. Banerjee, Michele L. Lage, Xueyin N. Huang, Stephen H. Smith, Samir Saba, Jennifer Rager, David A. Conner, Andrzej M. Janczewski, Kimimasa Tobita, Joseph P. Tinney, Ivan P. Moskowitz, Antonio R. Perez-Atayde, Bradley B. Keller, Michael A. Mathier, Sanjeev G. Shroff, Christine E. Seidman, J. G. Seidman

Normalized force (i.e., ratio of force at a given pCa and maximally activated force at pCa = 4.33) developed at a range of Ca2+ concentrations was assessed at sarcomere lengths 1.9 µm (Tnnt2+/−/TGWT •, Tnnt2+/−/TGK210Δ ▪) and 2.3 µm (Tnnt2+/−/TGWT ○, Tnnt2+/−/TGK210Δ □). There was a rightward shift of the force-pCa curve in Tnnt2+/−/TGK210Δ muscle, indicating Ca2+ desensitization. Values are mean±SE (n = 10 for Tnnt2+/−/TGWT and n = 7 for Tnnt2+/−/TGK210Δ).


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