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Non-Leukemogenic ICN Chimeras are Defective in Growth Rescue of “Notch1-Addicted” T-ALL Cells.

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posted on 13.10.2011, 01:39 by Jon C. Aster, Nick Bodnar, Lanwei Xu, Fredrick Karnell, John M. Milholland, Ivan Maillard, Gavin Histen, Yunsun Nam, Stephen C. Blacklow, Warren S. Pear

The Notch1-dependent murine T-ALL cell lines T6E and G4A2 were transduced with empty MigRI virus or the indicated forms of ICN and monitored for growth in the presence of the gamma-secretase inhibitor (GSI) compound E (1 microM). ICN1(A2), ICN1 backbone containing the ANK domain of Notch2; ICN1(A4), ICN1 backbone containing the ANK domain of Notch4; ICN1(A4r2-7), ICN1 backbone containing ANK repeats 2–7 of Notch4.

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