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NTS GLP-1R activation preferentially affects intake of palatable food but not chow.

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posted on 20.03.2015, 04:14 by Jennifer E. Richard, Rozita H. Anderberg, Andreas Göteson, Fiona M. Gribble, Frank Reimann, Karolina P. Skibicka

Direct NTS GLP-1R stimulation with Ex4 suppressed the intake of palatable food (peanut butter) but not chow when both were offered simultaneously. The effect of Ex4 had a short latency (noted 1h after injection), and lasted throughout the 6h of measurements. The food intake data are represented as grams eaten (A), as calories consumed, since the two foods differ in their caloric density (B), and as the fraction of total intake (by calories) that was represented by the palatable peanut butter intake(C). Data are expressed as mean ±SEM. n = 12 per each treatment group. * p<0.05, ** p<0.01, *** p<0.005.