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NELL2 regulates N-cadherin expression through the ERK signaling.

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posted on 21.01.2014, 03:43 by Dong Hee Kim, Han Rae Kim, Eun Jung Choi, Dong Yeol Kim, Kwang Kon Kim, Byung Sam Kim, Jeong Woo Park, Byung Ju Lee

P19 cells permanently transfected with NELL2 expression vectors were treated with 5 µM U0126 (a MEK inhibitor) in the presence or absence of 1 µM RA for 4 days. (A) Representative Western blots showing effect of U0126 on the ERK phosphorylation and N-cadherin and c-Fos expression. (B–D) Data showing the U0126-induced changes in phosphorylation of ERK (B) and expression of N-cadherin (C) and c-Fos (D), calculated from Western blot analyses. All experiments were repeated at least four times and data are presented as mean ± SEM. *, p<0.05; **, p<0.01; ***, p<0.001 versus control pcDNA group or between indicated groups.