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Mutations in pol γ increase mitochondrial flux in both directions but decrease only anterograde velocity.

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posted on 17.11.2009 by Rehan M. Baqri, Brittany A. Turner, Mary B. Rheuben, Bradley D. Hammond, Laurie S. Kaguni, Kyle E. Miller

(A) Bidirectional mitochondrial flux is increased significantly in segmental nerves of heterozygous tam3 and heteroallelic combination of pol γ β1/β2 and tam3/tam9; numbers at the base of columns indicate number of nerves assayed. (B) There is no significant change in the density of docked mitochondria in tam3/tam9 mutants; numbers at the base of columns indicate number of nerves assayed. (C) Average velocity of anterograde run is decreased significantly in heterozygous and heteroallelic pol γ mutants while average velocity of retrograde runs is affected; numbers at the base of columns indicate number of mitochondria traced. All error bars represent 95% confidence intervals. * indicates p<0.05 and ** indicates p<0.001 from Student's t-test.

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