Mutations in pol γ increase mitochondrial flux in both directions but decrease only anterograde velocity.
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(A) Bidirectional mitochondrial flux is increased significantly in segmental nerves of heterozygous tam3 and heteroallelic combination of pol γ β1/β2 and tam3/tam9; numbers at the base of columns indicate number of nerves assayed. (B) There is no significant change in the density of docked mitochondria in tam3/tam9 mutants; numbers at the base of columns indicate number of nerves assayed. (C) Average velocity of anterograde run is decreased significantly in heterozygous and heteroallelic pol γ mutants while average velocity of retrograde runs is affected; numbers at the base of columns indicate number of mitochondria traced. All error bars represent 95% confidence intervals. * indicates p<0.05 and ** indicates p<0.001 from Student's t-test.