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Mutagenic Mechanisms of IAP and ETn Insertions
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posted on 2013-02-22, 08:50 authored by Irina A Maksakova, Mark T Romanish, Liane Gagnier, Catherine A Dunn, Louie N. van de Lagemaat, Dixie L MagerIAP and ETn insertions were classified by their mechanism of gene disruption. Well documented instances of aberrant transcription initiation (5'-terminus) and polyadenylation (3'-terminus) were counted, as well as aberrant splicing and exon skipping (internal disruption). Insertions that cause gene disruption by multiple mechanisms (Table S1) were counted once in each relevant class.
