Morbid obesity in Leptin145E/145E mice.
(A) Increased body weight in Leptin145E/145E mice compared with their Leptin145E/+ and Leptin+/+ littermates. (B) Growth curves and photograph of male Leptin145E/145E mice (n = 5) and their Leptin+/+ littermates (n = 9). (C) Body lengths of 4-month-old male Leptin145E/145E and Leptin+/+ mice. (D) Organ weights from Leptin145E/145E (n = 11) and Leptin+/+ mice (n = 19). (E) Liver histology of Leptin145E/145Eand Leptin+/+ mice. Numbers of mice are inside bars. **P<0.01 and ***P<0.001 between two genotypes.