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Morbid obesity in Leptin145E/145E mice.

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posted on 20.02.2013, 21:55 by Chen-Jee Hong, Pei-Jane Tsai, Chih-Ya Cheng, Chuan-Kai Chou, Huei-Fen Jheng, You-Chung Chuang, Chia-Ning Yang, Ya-Tzu Lin, Chih-Wei Hsu, Irene H. Cheng, Shiow-Yi Chen, Shih-Jen Tsai, Ying-Jay Liou, Yau-Sheng Tsai

(A) Increased body weight in Leptin145E/145E mice compared with their Leptin145E/+ and Leptin+/+ littermates. (B) Growth curves and photograph of male Leptin145E/145E mice (n = 5) and their Leptin+/+ littermates (n = 9). (C) Body lengths of 4-month-old male Leptin145E/145E and Leptin+/+ mice. (D) Organ weights from Leptin145E/145E (n = 11) and Leptin+/+ mice (n = 19). (E) Liver histology of Leptin145E/145Eand Leptin+/+ mice. Numbers of mice are inside bars. **P<0.01 and ***P<0.001 between two genotypes.

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