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Monoterpene indole alkaloid pathway.

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posted on 26.12.2012 by Elsa Góngora-Castillo, Kevin L. Childs, Greg Fedewa, John P. Hamilton, David K. Liscombe, Maria Magallanes-Lundback, Kranthi K. Mandadi, Ezekiel Nims, Weerawat Runguphan, Brieanne Vaillancourt, Marina Varbanova-Herde, Dean DellaPenna, Thomas D. McKnight, Sarah O’Connor, C. Robin Buell

The key intermediate strictosidine is formed by condensation of tryptamine, which contributes the indole ring, and secologanin, which is produced from the monoterpene geraniol. In various plants, strictosidine is further metabolized to generate over 2,500 monoterpene indole alkaloids. Solid lines indicate single enzymatic steps; dashed lines indicate multiple steps.