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Model of the intracellular pathways involved in PACAP-induced RAGE shedding.

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posted on 2013-02-20, 01:41 authored by Verena V. Metz, Elzbieta Kojro, Dorothea Rat, Rolf Postina

In this study we demonstrated an involvement of MAP kinase, PI3-kinase, PKC and CaMKII in PAC1 receptor-induced activation of metalloproteinase-mediated RAGE shedding. Molecular mechanisms linking signaling cascades with metalloproteinase activation are still unknown (dotted lines). CaMKII: calmodulin-dependent protein kinase II; DAG: diacylglycerol; IP3: inositol 1,4,5-triphosphate; MAP kinase: mitogen-activated protein kinase; PI3-kinase: phosphatidylinositol 3-kinase.

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