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Model of a positive regulatory loop of IFN-γ-IL-18 signaling in memory CD8+ T cell expansion.

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posted on 2013-02-21, 10:19 authored by Yoshiko Iwai, Hiroaki Hemmi, Olga Mizenina, Shoko Kuroda, Koji Suda, Ralph M. Steinman

Unlike naïve CD8+ T cells, memory CD8+ T cells can provide an early source of IFN-γ to stimulate more IL-18 production from DCs. This positive loop of IFN-γ-IL-18 signaling may play an amplifying role in the acceleration of CD8+ T cell expansion in memory response rather than in primary response.

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