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Median IFNγ ELISpot Responses to PPD, antigen 85A protein, and SPP, up to 52 Weeks Post-Vaccination.

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posted on 16.06.2009, 01:29 by Kathryn T. Whelan, Ansar A. Pathan, Clare R. Sander, Helen A. Fletcher, Ian Poulton, Nicola C. Alder, Adrian V. S. Hill, Helen McShane

Median IFNγ ELISpot responses were assessed for PBMC from subjects in the BCG-BCG and BCG-MVA85A vaccination regimens against: (A) Tuberculin PPD; (B) Purified antigen 85 protein; (c) summed pooled peptide (SPP) of antigen 85A peptides. (d) A dot plot of AUC0–52weeks values calculated for PPD, antigen 85A protein, and SPP, and statistical analyses performed using Mann-Whitney test to compare results from BCG-BCG and BCG-MVA85A subjects. The results demonstrate significantly higher responses to antigen 85A protein (p = 0.009) and SPP (p = 0.0001) in BCG-MVA subjects compared with BCG-BCG subjects.