Maternal duplication 7p animals show a significant increase in norepinepherine levels in striatum, hippocampus and cerebellum.

Maternal duplication animals that express higher levels of Ube3a than their wild type littermates also showed a significant increase in norepinepherine levels (unpaired t-test, p≤0.05). Elevated norepinepherine levels were also detected in Ube3a deficient animals in the striatum, but not other regions of the brain. Paternal duplication animals that do not demonstrate elevated levels of Ube3a did not show any changes in norepinepherine in the brain regions tested. In all cases, norepinepherine levels for each genotype were compared to wild type littermates from each cross (100%). Significant differences were found at p≤0.05 for all groups (n = 6). *p≤0.05 compared to wild type littermate.