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Marked colitis in C. rodentium infected and aged TLR4−/− x IL-10−/− (DKO) mice colonized with Helicobacter spp.

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posted on 19.10.2010, 00:54 by Megan E. McBee, Yu Zeng, Nicola Parry, Cathryn R. Nagler, Steven R. Tannenbaum, David B. Schauer

Histological scores for inflammation, epithelial defects, edema, hyperplasia, and dysplasia in the colon for uninfected (Cr, ▪) and C. rodentium infected (Cr+, □) mice at 14 DPI (A) and Helicobacter spp. negative (Hsp, ▪) or positive (Hsp+, □) aged DKO mice (C). All scores were summed to form the histological activity index for individual mice. All pairings are *** P<0.0001 by Mann-Whitney test. (B) Representative H&E stained colon section from Cr (left panel) and Cr+ (right panel) mice at 14 DPI. (D) Representative H&E stained colon section from Hsp (left panel) and Hsp+ (right panel) DKO mice. Original magnification 100×.