Marked colitis in C. rodentium infected and aged TLR4−/− x IL-10−/− (DKO) mice colonized with Helicobacter spp.
Histological scores for inflammation, epithelial defects, edema, hyperplasia, and dysplasia in the colon for uninfected (Cr−, ▪) and C. rodentium infected (Cr+, □) mice at 14 DPI (A) and Helicobacter spp. negative (Hsp−, ▪) or positive (Hsp+, □) aged DKO mice (C). All scores were summed to form the histological activity index for individual mice. All pairings are *** P<0.0001 by Mann-Whitney test. (B) Representative H&E stained colon section from Cr− (left panel) and Cr+ (right panel) mice at 14 DPI. (D) Representative H&E stained colon section from Hsp− (left panel) and Hsp+ (right panel) DKO mice. Original magnification 100×.