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MR blockade without context re-exposure has no effect on subsequent fear expression.

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posted on 20.02.2013, 13:53 by Ming Zhou, Merel Kindt, Marian Joëls, Harm J. Krugers

A) Behavioral procedure for the experiment. B) Spironolactone was injected 23 hours after training in the absence of re-exposure to the fearful context on day 2. No effect of spironolactone on contextual memory retention was found twenty four hours (day 3) or one month later (n = 6 mice per group).

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