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MICA/B+ cells in the intraepithelial compartment.

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posted on 13.09.2013 by Yessica L. Allegretti, Constanza Bondar, Luciana Guzman, Eduardo Cueto Rua, Nestor Chopita, Mercedes Fuertes, Norberto W. Zwirner, Fernando G. Chirdo

A.- Immunofluorescent confocal microscopic analysis on small intestinal sections showing CD7+ cells (green), MICA/B+ cells (red) and nuclei (blue). (i) Mild enteropathy sample (ii) Enlarged section of (i). (iii) Severe enteropathy sample. (iv) Duodenal section from a healthy control. Intraepithelial and lamina propria compartments were delimited in the picture with a thin line (scan zoom 0.7, magnification 100×). B.- Numbers of CD7+MICA/B+ were determined per unit of muscularis mucosae m.m. using immunofluorescent microscopy on duodenal sections of 11 healthy controls, 9 patients with mild enteropathy and 4 patients with severe enteropathy. Percentage of CD7+MICA+ cells (left plot) and total number of CD7+ cells (right plot) were depicted. ** p≤0.01, (Non parametric Kruskal wallis test followed by the Dunns multiple-comparison posttest).

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