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MHC class I is expressed on axons in demyelinated lesions.

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posted on 30.08.2010, 00:52 by Chandra Deb, Reghann G. LaFrance-Corey, William F. Schmalstieg, Brian M. Sauer, Huan Wang, Christopher L. German, Anthony J. Windebank, Moses Rodriguez, Charles L. Howe

MHC class I expression colocalizes with dysmorphic axons immunostained for neurofilament. (A, C) MHC class I expression was observed in the 90 dpi spinal cord on fiber-like structures (red channel in C). (B, C) These same structures expressed neurofilaments and exhibited a dysmorphic pattern consistent with injured axons (green channel in C). Arrowheads point to the same structures in (A) and (B).

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