MHC class I is expressed on axons in demyelinated lesions.
MHC class I expression colocalizes with dysmorphic axons immunostained for neurofilament. (A, C) MHC class I expression was observed in the 90 dpi spinal cord on fiber-like structures (red channel in C). (B, C) These same structures expressed neurofilaments and exhibited a dysmorphic pattern consistent with injured axons (green channel in C). Arrowheads point to the same structures in (A) and (B).