METH-induced increase in synaptic transmission does not require stimulation, and is transient- returning to baseline within and hour.

Also, METH effects on baseline synaptic transmission are not dependent on NMDA receptors. (A) METH increase in synaptic transmission is not long-lasting, and does not require stimulation. Summary plot of normalized fEPSP slope measurements recorded in the CA1 region of the hippocampus. Results are from METH-treated slices. Stimulator turned off from t = 15 to t = 30. Error bars show ± SEM. (B) The effects of METH on baseline synaptic transmission are not altered by blockade of NMDA receptors. Summary plot of normalized fEPSP slope measurements recorded in the CA1 region of the hippocampus. Result are from DL-APV + METH-treated slices. Error bars show ± SEM.