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Lyp-W266 variant loses its function in T cell activation and its pH profile of enzyme activity.

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posted on 27.08.2012, 01:47 by Jing Liu, Ming Chen, Rong Li, Fan Yang, Xuanren Shi, Lichao Zhu, Hong-Mei Wang, Wei Yao, Qiji Liu, Fan-Guo Meng, Jin-Peng Sun, Qi Pang, Xiao Yu

(A) Comparison of Lyp wild type and W266 variant on TCR-induced AP-1 transcriptional activity. (B) pH-Kcat profile of the pNPP hydrolysis catalyzed by Lyp wild type and R266W mutant.

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