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Loss of Gsα in NCCs results in severe craniofacial malformations.

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posted on 2016-02-09, 09:02 authored by Run Lei, Ke Zhang, Yanxia Wei, Min Chen, Lee S. Weinstein, Yang Hong, Minyan Zhu, Hongchang Li, Huashun Li

(A, B) P0 Wnt1-cre;Gsαf/f mutant and control. Wnt1-cre;Gsαf/f mutant mice become cyanotic and die within hours after birth, exhibit domed skull, shortened maxilla and mandible and exposed tongue. (C-F) The gross appearance of Wnt1-cre;Gsαf/f mutants (C and E) and controls (D and F) are identical at E10.5 and E12.5 respectively. (G, H) E14.5 Wnt1-cre;Gsαf/f mutant and control. Wnt1-cre;Gsαf/f embryos show short snout, round face and hypertelorism. (I-L) E16.5 and E18.5 Wnt1-cre;Gsαf/f mutants (I and K) display exposed tongues and shortened maxilla and mandible compare to controls (J and L).