Liraglutide and exendin-4 are effective weight management drugs in high fat-fed C57BL/6 mice, but liraglutide is more effective at improving glucose tolerance.
The weight of male C57BL/6 mice was monitored on a weekly basis over a period of eight weeks (white area) on high fat (HFD) or normal chow diet (ND), followed by 75 days (grey area) of daily intraperitoneal injections of saline, or a GLP-1 mimetic- liraglutide (panels A–C), exendin-4 (panels D–F), or sitagliptin (panels G–I). Intra-peritoneal glucose tolerance tests were performed after 75 days of treatment (B–C, E–F, H–I). Time courses (B, E, H) and the corresponding areas under the curve (C, F, I) are shown. p≤0.001, ***; p≤0.01, **, n = 3–7 mice.