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Levels of 8-hydroxy-2′ deoxyguanosine (8-OHdG) in the lungs after hemorrhagic shock and resuscitation (HSR).

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posted on 07.05.2013, 02:25 by Junko Kosaka, Hiroshi Morimatsu, Toru Takahashi, Hiroko Shimizu, Susumu Kawanishi, Emiko Omori, Yasumasa Endo, Naofumi Tamaki, Manabu Morita, Kiyoshi Morita

Lungs from the HSR group rats treated with or without biliverdin (BV) were excised 3 h after resuscitation and mitochondrial 8-OHdG levels were measured. Data are presented as means ± standard deviation (n = 5 per group). Statistical analysis was performed using analysis of variance followed by Tukey–Kramer honestly significant difference test. *p<0.05 vs. vehicle/sham; p<0.05 vs. BV/sham; #p<0.05 vs. vehicle/HSR. Vehicle/sham, vehicle-administered animals subjected to sham surgery; BV/sham, BV-administered animals subjected to sham surgery; vehicle/HSR, vehicle-administered animals subjected to HSR; BV/HSR, BV-administered animals subjected to HSR.