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Lack of Endogenous NE increases apoptosis of hHSC.

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posted on 03.09.2013 by Barbara Sigala, Chad McKee, Junpei Soeda, Valerio Pazienza, Maelle Morgan, Ching-I Lin, Clare Selden, Sara Vander Borght, Gianluigi Mazzoccoli, Tania Roskams, Manlio Vinciguerra, Jude A. Oben

Absence of serum induced marked apoptosis (a), reduced by presence of serum (b), PDGF (c) or NE (d). PRZ markedly induced hHSC apoptosis more than serum deprivation (e), the effect of PRZ was abrogated by NE (f). Results shown are from 1 typical experiment. Similar results have been obtained on at least 2 other occasions. PRZ significantly induced apoptosis compared to serum alone or compared to NE alone (Serum alone 3±0.6% vs PRZ 11±3%, p<0.05,n = 3; NE 4±0.2% vs PRZ 11±3%, p<0.05,n = 3).

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