LacZ expression pattern in Ifitm1^tm1IEG/wt embryos from E8.5 to E11.5.

(A – E) At E8.5 strong expression was found in the future brain and the neural tube. Weak expression was detected in the allantois. (F – I) At E9.5 lacZ expression was detected in the future brain, the primordial gut, the somites and the presomitic mesoderm. The anlage of the lung was the anterior boundary of reporter gene expression in the trunk region (see dashed line). (J – M) At E10.5 the reporter gene expression pattern was similar to the one at E9.5. The expression in the ventral brain was extended along the anterior-posterior axis. (N – Q) At E11.5 lacZ expression decreased in the PSM and in somites. Weak expression was detected in the brain and a new expression domain developed in the urogenital ridge. Abbreviations: a – allantois, b – brain, g – primordial gut, la – anlage of the lung, nt – neural tube, PSM – presomitic mesoderm, s – somite, ur – urogenital ridge.