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LD plot among common and low-frequent SNPs in the SERPINA1 gene within the SAPALDIA study.

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posted on 22.08.2013, 02:33 by Gian Andri Thun, Medea Imboden, Ilaria Ferrarotti, Ashish Kumar, Ma'en Obeidat, Michele Zorzetto, Margot Haun, Ivan Curjuric, Alexessander Couto Alves, Victoria E. Jackson, Eva Albrecht, Janina S. Ried, Alexander Teumer, Lorna M. Lopez, Jennifer E. Huffman, Stefan Enroth, Yohan Bossé, Ke Hao, Wim Timens, Ulf Gyllensten, Ozren Polasek, James F. Wilson, Igor Rudan, Caroline Hayward, Andrew J. Sandford, Ian J. Deary, Beate Koch, Eva Reischl, Holger Schulz, Jennie Hui, Alan L. James, Thierry Rochat, Erich W. Russi, Marjo-Riitta Jarvelin, David P. Strachan, Ian P. Hall, Martin D. Tobin, Morten Dahl, Sune Fallgaard Nielsen, Børge G. Nordestgaard, Florian Kronenberg, Maurizio Luisetti, Nicole M. Probst-Hensch

Shading represent r2 values, whereas numbers represent D′ values (no number equals D′ = 1). Red framed SNPs are independently associated with AAT serum levels after forward selection stepwise regression modeling. Rs17580 is the PI S variant and rs28929474 is the PI Z variant.

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