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Kto and Skd regulate the Imd pathway in the L3-5 cell line.

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posted on 25.09.2012, 00:13 by Yang Chen, Yuemei Dong, Simone Sandiford, George Dimopoulos

A) Silencing of Kto impairs the IMD pathway, and this impairment cannot be rescued by over-expression of PGRP-LC1; B) over-expression of Rel2 abolished the effect of silencing Kto; C) over-expression of IMD did not rescue the phenotype caused by silencing Kto; D) silencing Kto and Skd resulted in similar phenotypes. Shown are representative results from one of three independent repeats with similar trends. *, p<0.05; ***, p<0.001.

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