Karyogram and common chromosomal aberrations.
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posted on 2012-11-12, 01:17 authored by Johannes Fredebohm, Michael Boettcher, Christian Eisen, Matthias M. Gaida, Anette Heller, Shereen Keleg, Jörg Tost, Karin M. Greulich-Bode, Agnes Hotz-Wagenblatt, Mark Lathrop, Nathalia A. Giese, Jörg D. HoheiselA representative karyogram of JoPaca-1 is shown here. JoPaca-1 is a tetra- to penta-ploidic cell line. Below the overview picture, the five most commonly observed aberrations in 26 karyograms are presented. Translocations could be identified by hybridization of differently coloured probes resulting in dual-coloured chromosomes. Inversion of chromosome 13 (i13) is the fusion of two q-arms at the kinetochore. The Y-chromosome is often lost in tumour cells as it is in this representation.
