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Involvement of COX metabolites in MetS MP-induced vascular hypo-reactivity.

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posted on 2011-11-15, 00:59 authored by Abdelali Agouni, Pierre-Henri Ducluzeau, Tarek Benameur, Sébastien Faure, Martina Sladkova, Lucie Duluc, Georges Leftheriotis, Olga Pechanova, Mirela Delibegovic, Maria Carmen Martinez, Ramaroson Andriantsitohaina

(A–D) Concentration-response curves to 5-HT of aortic rings from mice treated with either vehicle (CTL, n = 7), HS MPs (n = 8) or MetS MPs (n = 8) in the absence or presence of COX inhibitor (indomethacin, 10 µmol/l). (E–H) Concentration-response curves to 5-HT of aortic rings from mice treated with either vehicle (CTL, n = 7), HS MPs (n = 8) or MetS MP (n = 8) in the absence or presence of COX-2 inhibitor (NS398, 1 µmol/l). ***P<0.001 vs. absence of the inhibitor; ## P<0.01 MetS MPs vs. CTL.

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