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Investigation of the extrinsic and intrinsic apoptosis pathway after IITT+F treatment.

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posted on 01.04.2015 by Sarah Jean Boeddeker, Dunja Maria Baston-Buest, Tanja Fehm, Jan Kruessel, Alexandra Hess

Analysis of Caspase-8 and -9 activation of treated cells vs. untreated controls in non-differentiated (St-T1, red bar; KdS1, blue bar) and decidualized dSt-T1, bright red bar; dKdS1, bright blue bar) ESCs after treatment with IITT+F. Untreated controls were assigned being 1 and enzymatic activity of caspases after treatment was determined as fold induction vs. controls and given as mean±SEM of n = 3 independent experiments, *p<0.05 Sdc-1 wildtype vs. Sdc-1 kd cells, ✝p<0.05 untreated controls vs. treated.