Intra-MnPO injection of PaTx1 shifts the CBT circadian profile in w-t mice.

A. CBT (upper panel) and MA (lower panel) responses to intra-MnPO injection of PaTx1 (800 nM, 0.2 µL) (black) and aCSF (0.2 µL) (red) injections in Kv4.2−/− mice B. CBT (upper panel) and MA (lower panel) responses to intra-MnPO injection of PaTx1 (800 nM, 0.2 µL) (black) and aCSF (0.2 µL) (red) injections in w-t mice. The toxin induced a ∼1 h delay in the CBT rise associated with the active phase (two-way repeated measures ANOVA followed by t-tests for each time point, * P<0.05) and did not affect motor activity (two-way repeated measures ANOVA followed by t-tests for each time point, P>0.3). A–B. The line graphs represent averages±S.D. through the 24 h recording period. Experiments were carried out in parallel in 2 groups of 6 and Kv4.2−/− and w-t mice, respectively.