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Interactions between delphinidin-3-O-arabinoside and the transcription domain of hepatocyte nuclear factor-1α (HNF-1α).

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posted on 28.09.2015, 03:17 by Luis M. Real Hernandez, Junfeng Fan, Michelle H. Johnson, Elvira Gonzalez de Mejia

The conformation of delphinidin-3-O-arabinoside with the highest binding affinity for the transcription domain of HNF-1α attached to a DNA construct from PDB file 1IC8 is shown (A) with a lilac surface representing a general surface of the domain (A, C). Amino acids in the transcription domain of HNF-1α had electrostatic (pink) and van der Waals (green) interactions with delphinidin-3-O-arabinoside (B). Hydrogen bonds are shown as one headed, dashed arrows formed with amino acid main-chain (green) or side-chain (blue) atoms. A 3-dimensional representation of delphinidin-3-O-arabinoside interacting with the transcription domain of HNF-1α is shown (C) with certain interacting amino acids highlighted and labeled to show their relative position.