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Insulator Classes Are Characteristic of Promoter Classes.

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posted on 13.01.2011 by Elizabeth A. Rach, Deborah R. Winter, Ashlee M. Benjamin, David L. Corcoran, Ting Ni, Jun Zhu, Uwe Ohler

(A) Human CTCF had higher occurrences in BP and WP promoters (p<10E-11). (B,C,D) Two classes of fruit fly insulators [22] were compared to promoters classes on embryonic data from 0–12 hr. Class I insulators (including dCTCF, CP190, and BEAF32) supported the same pattern of increased BP and WP levels as observed for human CTCF. (E,F) Class II insulators had equal occurrence across promoter classes, with Su(Hw) not being bound to proximal promoter regions. (G,H) ChIP-chip profiles of the chromatin-remodeling transcription factor GAF, as well as presence of GAGA binding sites in the genome, showed a clear enrichment at NP promoters (p<10E-02).

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