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Insertion mutant but active urease can affect bacterial colonisation.

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posted on 29.11.2010 by Tobias D. Schoep, Alma Fulurija, Fayth Good, Wei Lu, Robyn P. Himbeck, Carola Schwan, Sung Sook Choi, Douglas E. Berg, Peer R. E. Mittl, Mohammed Benghezal, Barry J. Marshall

a) Persistence over 15 months expressed as percentage of colonised mice at each time point (n = 5–15). b) Colonisation level of mice infected with H. pylori expressing mutant urease after 15 months (n = 5; median displayed). c) Persistence of H. pylori expressing mutant urease as indicated by anti-H. pylori IgG levels (n = 12–20; median displayed). Strains were recombinant at either sites 1, 4 or 8 in urease. d) Comparison of anti-H. pylori IgG and anti-UreB IgG levels resulting from colonisation of mice for 3 months with X47 expressing wild-type urease, X47 (wt), or urease mutant at site 8, X47 (site8), (n = 10–20; median displayed).

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